abstract：BACKGROUND:Skip metastasis to mediastinal lymph nodes is a well-known phenomenon in non-small cell lung cancer (NSCLC). Little is reported in the literature about its clinical importance. It is still under discussion whether any prognostic differences exist between resected NSCLC with either skip metastases or continuo...

journal_title：Journal of surgical oncology

authors： Prenzel KL,Mönig SP,Sinning JM,Baldus SE,Gutschow CA,Grass G,Schneider PM,Hölscher AH

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Alterations in mitochondrial DNA have been identified in a number of solid tumor types, including gastric, head and neck, breast, colorectal, lung, and bladder carcinomas. Recently, a homopolymeric C stretch (D310) located within the noncoding D-loop of the mitochondrial genome was identified and described a...

journal_title：Journal of surgical oncology

authors： Tong BC,Ha PK,Dhir K,Xing M,Westra WH,Sidransky D,Califano JA

更新日期：2003-03-01 00:00:00

abstract：:The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which induce and stimulate bone formation, was performed and revealed ove...

journal_title：Journal of surgical oncology

authors： Kypson AP,Morphew E,Jones R,Gottfried MR,Seigler HF

更新日期：2003-02-01 00:00:00

abstract：:Surgical resection for selected patients with hepatic metastases from colorectal cancer can cure approximately one-fourth of these patients. The addition of regional chemotherapy as an attempt to improve this statistic has been extensively investigated in clinical trials. As part of a multidisciplinary educational pro...

journal_title：Journal of surgical oncology

authors： Khushalani NI,McKinley BP,Gibbs JF,Leichman CG,Petrelli NJ

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Uncertainty exists about the value of cancer therapy in patients aged 90 years and older. Because of the relative paucity of these patients, as well as the possibility of selection bias in any one institution, the use of a large, total population-based cancer registry was employed. METHODS:Th...

journal_title：Journal of surgical oncology

authors： Saltzstein SL,Behling CA

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Some schwannomas in the central nervous system may demonstrate relatively aggressive behavior in pathological findings and clinical course. We evaluate the diagnostic values of telomerase activity and telomere length in the clinicopathological behavior of schwannomas. METHODS:Thirty surgical ...

journal_title：Journal of surgical oncology

authors： Chen HJ,Cho CL,Liang CL,Lu K,Lin JW

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:With the increasing use of sentinel lymph node biopsy, a growing proportion of women with early-stage invasive breast cancer are undergoing breast conserving surgery without a formal axillary lymph node dissection. A frequent question raised is whether the level I-II axillary lymph nodes are t...

journal_title：Journal of surgical oncology

authors： McCormick B,Botnick M,Hunt M,Petrek J

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We performed a retrospective analysis to assess the influence of different prognostic factors, including the International Prognostic Index (IPI), that can predict the outcome in patients with primary large bowel lymphoma (Stage IE) treated with combined therapy (surgery followed by chemothera...

journal_title：Journal of surgical oncology

authors： Avilés A,Neri N,Huerta-Guzmán J

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The poorer outcome amongst younger breast cancer patients continues to be an issue of debate. In order to clarify the prognostic value of patient age, we retrospectively analyzed the data of 1098 breast cancer patients. METHODS:Patients were divided into two groups based on the age 35 (Group ...

journal_title：Journal of surgical oncology

authors： Park BW,Kim SI,Kim EK,Yang WI,Lee KS

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Variants of CD44 have been proposed to be important in promoting tumor progression and metastasis. We attempted to determine the expression of CD44v6 product in advanced gastric cancer and to evaluate its prognostic value. METHODS:The expression of CD44v6 was analyzed immunohistochemically in...

journal_title：Journal of surgical oncology

authors： Yamaguchi A,Goi T,Yu J,Hirono Y,Ishida M,Iida A,Kimura T,Takeuchi K,Katayama K,Hirose K

更新日期：2002-04-01 00:00:00

abstract：:In the twentieth century, lymph node dissection based on metastatic distribution has developed as the standard procedure for surgical management of gastrointestinal cancer [1]. The fear that invisible micrometastases might be present has encouraged aggressive resection with lymphadenectomy to control the disease. Howe...

journal_title：Journal of surgical oncology

authors： Kitagawa Y,Kitajima M

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Preoperative positivity of serum tumor markers has been reported to be a prognostic factor in several neoplasms. The aim of this longitudinal study was to evaluate the correlation between CEA, CA 19-9, and CA 72-4 preoperative serum levels and the site of recurrence after curative surgery for ...

journal_title：Journal of surgical oncology

authors： Marrelli D,Pinto E,De Stefano A,de Manzoni G,Farnetani M,Garosi L,Roviello F

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Malignant mesothelioma is a lethal disease. Aggressive multimodality treatment protocols are reportedly associated with improved survival, but the apparent survival benefits may simply reflect patient selection and the variable natural history of this malignancy. Before embarking on our own pr...

journal_title：Journal of surgical oncology

authors： Merritt N,Blewett CJ,Miller JD,Bennett WF,Young JE,Urschel JD

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Immune status in the peritoneal cavity of patients with gastric cancer remains largely unknown. To clarify the clinical significance of the host immune response within the peritoneal cavity, we examined the levels of interferon-gamma (IFN-gamma), a type 1 cytokine, and interleukin-10 (IL-10), ...

journal_title：Journal of surgical oncology

authors： Majima T,Ichikura T,Seki S,Takayama E,Hiraide H,Mochizuki H

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Adjuvant radiotherapy for node positive breast cancer postmastectomy has been recommended by two previously published randomized controlled trials (RCT). The local-regional recurrence rates in the control arms, however, were considered by some critics to be excessive (> 25% at 10 years). Inadeq...

journal_title：Journal of surgical oncology

authors： Latosinsky S,Bear HD

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The purpose of this study was to compare the complications and functional outcome associated with the use of an irradiated allograft-implant composite or a bone-ingrowth modular tumor prosthesis for replacement of the knee joint after resection of a bone sarcoma from the distal femur or proxim...

journal_title：Journal of surgical oncology

authors： Wunder JS,Leitch K,Griffin AM,Davis AM,Bell RS

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We analyzed the clinicopathologic characteristics and tumor biology of metachronous bilateral breast carcinoma with regard to p53, HER2 and hormone receptor status. METHODS:A consecutive series of 54 female metachronous bilateral breast carcinoma patients treated at the National Cancer Center...

journal_title：Journal of surgical oncology

authors： Matsuo K,Fukutomi T,Tsuda H,Akashi-Tanaka S,Shimizu C,Hasegawa T

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Despite precipitous drop in the incidence of gastric carcinoma in Japan, it is still one of the leading causes of death associated with malignant disease. Once the contiguous organs are involved the prognosis becomes dismal. Prognostic factors governing the survival of patients with T4 gastric...

journal_title：Journal of surgical oncology

authors： Dhar DK,Kubota H,Tachibana M,Kinugasa S,Masunaga R,Shibakita M,Kohno H,Nagasue N

更新日期：2001-04-01 00:00:00

abstract：UNLABELLED:BACKGROUND AND OBJECTS: Matrix degradation, which is a critical event in the process of tumor invasion and metastasis, is considered to be caused by the action of proteolytic enzymes. METHODS:We examined the gelatinolytic activity of matrix metalloproteinase (MMP)-9, and the activity of active and inactive ...

journal_title：Journal of surgical oncology

authors： Kondo K,Kinoshita H,Ishikura H,Miyoshi T,Hirose T,Matsumori Y,Monden Y

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:To determine the prognostic significance of the colposcopic tumor size in the management of cervical cancer. METHODS:Clinicopathological analysis was performed in 751 consecutive patients with stage IB squamous cervical cancer who were surgically treated in a single institute. The colposcopic...

journal_title：Journal of surgical oncology

authors： Yanoh K,Takeshima N,Nishida H,Hirai Y,Toyoda N,Hasumi K

更新日期：2001-02-01 00:00:00

abstract：:Metastatic liver disease is the commonest cause of death in patients with colorectal cancer. A small proportion of these patients (10%) may be treated by surgical resection with five year survival approaching 35-40%. Alternative treatment modalities for localised hepatic disease include in situ ablative techniques tha...

journal_title：Journal of surgical oncology

authors： Muralidharan V,Christophi C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We studied antitumor effects and cell death induced by cationic liposome-mediated gene transfer of the herpes simplex virus thymidine kinase (HSV-tk) gene followed by ganciclovir treatment in cultured rat T9 glioma cells and in experimental gliomas produced from this cell line. METHODS:To tra...

journal_title：Journal of surgical oncology

authors： Yoshida T,Mizuno M,Taniguchi K,Nakayashiki N,Wakabayashi T,Yoshida J

更新日期：2001-01-01 00:00:00

abstract：:Pseudomyxoma peritonei is a rare neoplastic condition in that gelatinous intraperitoneal fluid collections and mucinous implants on the peritoneal surfaces and omentum are found. The pathological origin is usually an adenoma or well-differentiated adenocarcinoma of the appendix. A smaller number of cases arises from o...

journal_title：Journal of surgical oncology

authors： de Bree E,Witkamp A,Van De Vijver M,Zoetmulde F

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Ovarian metastases are reported to occur in 3-8% of women undergoing surgical resection of a primary colorectal adenocarcinoma. Information on clinical outcome after metastectomy for these patients is limited. Patients and Methods A computerized search of the medical record archive at the London Regional Can...

journal_title：Journal of surgical oncology

authors： Rayson D,Bouttell E,Whiston F,Stitt L

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Differences in the expression levels of Thyroglobulin (Tg), Thyroid peroxidase (TPO) and thyrotropin receptor (TSH-R) in primary and recurrent specimens under a suppressive serum TSH condition were elucidated in 26 papillary carcinoma patients. METHODS:Immunohistochemical detection was perfor...

journal_title：Journal of surgical oncology

authors： Tanaka K,Sonoo H,Yamamoto Y,Udagawa K,Kunisue H,Arime I,Yamamoto S,Kurebayashi J,Shimozuma K

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The effect of esophagectomy with three-field lymph node dissection for submucosal carcinoma of the thoracic esophagus remains controversial. The aim of this study was to evaluate the effect of esophagectomy with three-field lymph node dissection for submucosal carcinoma of the thoracic esophag...

journal_title：Journal of surgical oncology

authors： Igaki H,Kato H,Tachimori Y,Nakanishi Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Blue nevi are benign pigmented dermal lesions that can mimic cutaneous melanoma in appearance. Cellular components may infiltrate subcutaneous tissue. We present a complex case of cellular blue nevus (CBN) to demonstrate the ambiguous clinical appearance of these lesions and to provide an appr...

journal_title：Journal of surgical oncology

authors： Hoos A,Berho M,Blumencranz PW,Brady MS

更新日期：2000-08-01 00:00:00

abstract：:We herein describe an unusual late radiation-related complication requiring surgery in a 60-year-old male affected by anal epidermoid carcinoma. The patient presented with obstructed defecation and ulcerated perianal lesions. The perianal biopsies were positive for anal squamous carcinoma. Transanal diagnostic investi...

journal_title：Journal of surgical oncology

authors： Cicchini C,Stazi A,Ciardi A,Ghini C,Indinnimeo M

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:To determine how inhomogeneities in blood perfusion might affect the number of metastases that develop within an individual with cancer. METHODS:Experiments with lung metastases in mice, involving 320 treatment groups and 3165 mice, were reviewed. Inhomogeneities in the distribution of metast...

journal_title：Journal of surgical oncology

authors： Kendal WS

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We present the long-term functional results of a new technique for bladder substitution after cystectomy for bladder cancer in women. METHODS:Between 1991 and 1995, 10 women underwent radical cystectomy for bladder cancer with a new technique. We created a detubularized rectosigmoid neobladde...

journal_title：Journal of surgical oncology

authors： Mearini E,Mearini L,Zucchi A,Costantini E,Goracci G,Porena M

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Stages II and III rectal tumors are known as locally advanced rectal cancer (LARC) because they are characterized by a high incidence of local and distant relapses and a low probability of long-term survival. Adjuvant treatments have been advocated to ameliorate overall survival (OS), local re...

journal_title：Journal of surgical oncology

authors： Bufalari A,Boselli C,Giustozzi G,Moggi L

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The genetic alterations involved in extrahepatic bile duct (EHBD) cancer are poorly understood. Our aim was to identify aberrations of the K-ras, p53, and APC genes in EHBD cancer. METHODS:We investigated aberrations of these genes in 52 EHBD cancers using polymerase chain reaction (PCR) sing...

journal_title：Journal of surgical oncology

authors： Suto T,Habano W,Sugai T,Uesugi N,Funato O,Kanno S,Saito K,Nakamura Si

更新日期：2000-03-01 00:00:00

abstract：:In hemicorporectomy, or translumbar amputation, the bony pelvis, pelvic contents, lower extremities, and external genitalia are removed following disarticulation of the lumbar spine and transection of the spinal cord. Malignancies of the pelvic organs, skin, or musculoskeletal structures, usually locally advanced, may...

journal_title：Journal of surgical oncology

authors： Weaver JM,Flynn MB

更新日期：2000-02-01 00:00:00

abstract：:Locally recurrent cancer of the rectum has been under-recognized as a complication, although it affects up to 40% of patients treated with surgery alone. Even in the best centers, rates average 25%. While radiotherapy may reduce recurrence, it is now apparent that total mesorectal excision is the most effective modali...

journal_title：Journal of surgical oncology

authors： Temple WJ,Saettler EB

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A previous study of ours indicated that platelet-derived growth factor-A (PDGF-A) mRNA expression in biopsy specimens can identify a subgroup of high-risk gastric carcinoma patients, while clinicopathologic studies have shown that lymph node involvement is an important risk factor for predicti...

journal_title：Journal of surgical oncology

authors： Kuwahara A,Katano M,Nakamura M,Fujimoto K,Miyazaki K,Mori M,Morisaki T

更新日期：1999-11-01 00:00:00

abstract：:Dramatic improvements in morbidity and mortality rates following liver resections have been reported in the past decade. Consequently, the indications for hepatectomy are becoming more liberal. Many techniques of liver resection with or without vascular clamping have been reported with excellent clinical results. Tota...

journal_title：Journal of surgical oncology

authors： Zografos GN,Kakaviatos ND,Skiathitis S,Habib N

更新日期：1999-09-01 00:00:00

abstract：UNLABELLED:Application of subatmospheric pressure to sites injected with doxorubicin prevented ulcer formation in treated sites (0 ulcers/16 sites) compared to control wounds (10 ulcers/16 sites) in a pig model. BACKGROUND AND OBJECTIVES:Extravasation of doxorubicin hydrochloride (Adriamycin) frequently causes chronic...

journal_title：Journal of surgical oncology

authors： Morykwas MJ,Kennedy A,Argenta JP,Argenta LC

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Apoptosis is essential to maintain homeostasis in living organisms and occurs in a variety of tissues in response to both physiological and pathological stimuli. In breast cancer, most cytotoxic drugs and hormonal treatments induce apoptosis. We studied the relationships between apoptosis and ...

journal_title：Journal of surgical oncology

authors： Nishimura R,Nagao K,Miyayama H,Matsuda M,Baba K,Matsuoka Y,Yamashita H,Fukuda M,Higuchi A

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:There are no reports concerning surgical treatment on pulmonary metastases from gastric cancer. The aims of this study were to characterize patients with pulmonary metastasis from gastric cancer and to determine the efficacy of surgical therapy. METHODS:Between 1977 and 1993, 3,076 patients u...

journal_title：Journal of surgical oncology

authors： Kanemitsu Y,Kondo H,Katai H,Nakayama H,Asamura H,Tsuchiya R,Naruke T

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Tumor thickness is considered the single most important predictor of survival in clinically localized malignant melanoma. A recent study found tumor volume a more sensitive predictor of survival than thickness. Volume measurement, however, is complicated, time consuming, and based on biologica...

journal_title：Journal of surgical oncology

authors： Temple CF,Huchcroft SA,Hurlbut DJ,Davidson JS

更新日期：1998-10-01 00:00:00